Metabolic Regulation in Progression to Autoimmune Diabetes
Figure 4
Similarities between lipid changes observed in children who later progress to T1D and the early prediabetic changes present in female NOD mouse progressors.
(A) HMM state progression as a function of age in female NOD mice is similar for progressors and non-progressors. Each column shows the probabilities of being in the three states at a certain age, estimated by bootstrap. (B) Differences in lipidomic profiles (mean lipid concentrations) between progressors and non-progressors as a function of the progressive metabolic state, colored according to bootstrap-based confidence intervals. (C) Differences in lipid concentrations in diabetes progressors vs. non-progressors that generalize across the species. Mapping shown on the left is inferred from longitudinal lipidomic profiles from DIPP study children, including n = 56 progressors and n = 73 non-progressors [2] (Figure 3), and NOD female mice (same as in Figure 2).