Validation of Skeletal Muscle cis-Regulatory Module Predictions Reveals Nucleotide Composition Bias in Functional Enhancers
Figure 4
Phylogenetic depth analysis of TFBSs in responding and non-responding regions using phyloP (46-way, hg19).
The x-axis grouping indicates the species used to calculate the phyloP scores. TFBSs were searched using all vertebrate profiles from the JASPAR CORE collection using the threshold of 0.8. TFs with at least 2-fold increase in phyloP scores (46wayAll) in the TFBS positions over the non-TFBS positions in the responding regions were identified. The score ratios for these TFs were compared among the three region sets. a) Average phyloP scores for the predicted TFBS positions and non-TFBS positions in each region set. b) Ratios of phyloP scores for the TFBS positions and non-TFBS positions in each region set.