The What and Where of Adding Channel Noise to the Hodgkin-Huxley Equations
Figure 4
Analysis of responses of modified channel noise models to a step increase in current.
(A) Voltage trace obtained from the Markov chain model with channels and
channels. Input current is increased from
at
, onset time of the stimulus is marked by the gray arrow. (B) Means of fraction of open
and
channels for the voltage trace shown in (A). (C) Variance in the fraction of open
channels for the Markov chain and system size-based conductance noise models. (D) Variance in the fraction of open
channels for the Markov chain and system size-based conductance noise models. Means and variances were estimated from 5,000 repeated simulations of the channel noise models. (E) Histogram of spike times in response to the step increase in current described above. Solid lines show the mean of ten histograms computed from 500 spike times each and error bars represent the standard error in the mean. Gray arrow indicates the spike time of a deterministic version of the model.