Computation of Steady-State Probability Distributions in Stochastic Models of Cellular Networks
Figure 7
(A) A network diagram of Myc/Rb/E2F at the G1-S cell cycle checkpoint. (B) Comparison of the MGS predicted probability distribution (red) and the SDEs predicted distribution (green) of selected molecular species of the repressed and the activated state of the network. The solid lines represent Gaussian distributions fitted over all random samples corresponding to each method. (C) Convolution of extrinsic noise and combination of the repressed and the activated modes based on empirical data derived from SDE simulations, with the variance of the shift distribution separately optimized. Shown in red are MGS predicted distributions and green are SDEs predicted distributions of E2F with either low or high level of extrinsic noise as defined in the SDE framework. The SDE model and the associated parameters are described in detail in Lee et al [51].