Construction and Analysis of an Integrated Regulatory Network Derived from High-Throughput Sequencing Data
Figure 4
Hierarchical illustration of the integrated regulatory network.
(A) The C. elegans integrated gene regulatory network exhibits a 7-layer structure with 3 layers of TFs (red circles) and 4 layers of miRNAs (cyan circles). TF-TF and TF-miRNA regulatory interactions were shown as dark and light arrows respectively. Essential transcription factors are labeled by a blue circle. (B) TFs in the three layers show significant difference in their average number of regulatory miRNAs (left), average degree in protein-protein interaction network (middle) and tissue specificity (right).