High-Precision, In Vitro Validation of the Sequestration Mechanism for Generating Ultrasensitive Dose-Response Curves in Regulatory Networks
Figure 4
Simulation of the sequestration mechanism.
A simulation of equations 1 and 2 illustrates the range of [dep]/Kdprobe and Kdprobe/Kddep over which pseudo-Hill coefficients above 2 (gray area) and above 4 (dark area) are obtained. Shown in boxes are some of the experimental pseudo-Hill coefficients we have observed (the horizontal and vertical lines of data were taken from figures 2 and 3 respectively).