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A Mathematical Model of Muscle Containing Heterogeneous Half-Sarcomeres Exhibits Residual Force Enhancement

Figure 3

Stretch magnitude dependence of the force enhancement response.

(A) Tension responses in a simulated fiber containing 50 half-sarcomeres in series and an α value of 0.2 for various stretch magnitudes. The dashed trace represents tension under isometric conditions at the final length (L0). (B) Fiber length as a fraction of final length (L0). (C) Residual force enhancement magnitude (RFE) at each of the simulated stretch magnitudes. RFE was proportional to stretch magnitude, in agreement with many experimental measurements. Colors in each panel link tension, length, and RFE values that have the same stretch magnitude.

Figure 3

doi: https://doi.org/10.1371/journal.pcbi.1002156.g003