Bistability versus Bimodal Distributions in Gene Regulatory Processes from Population Balance
Figure 5
Population distribution for a system with bistability.
Both (A) and (B) use the same parameters shown in Table 2. Extracellular pheromone concentration is maintained at 13.5 nM for both simulations. Only noise term of protein and peptides are taken into consideration [48], [49]. Thirty thousand cells are used. (A) Outcome from single cell stochastic model described in Eq.(30). Due to stochasticity, bimodal distribution comes from initial unimodal distribution. Single cell stochastic model ignores the interaction between cells. Extracellular inhibitor is used only by the donor cell secreting it. (B) Outcome from PBM described in Eq.(29). The extracellular inhibitor is utilized by the whole population. The simulation outcome shows that the population effect leads to unimodal distribution.