Bistability versus Bimodal Distributions in Gene Regulatory Processes from Population Balance
Figure 4
Bimodal distribution results from no bistability.
The parameters used in this simulation are shown in Table 2 except for K4,2 = K4,1 = 0.001 (1/s). (A) The stationary distribution responding to different concentrations of extracellular pheromone, cCF10. As the concentration of pheromone increases, cell population migrates from state of low PrgB, viewed as off state, to state of high PrgB, viewed as on state. When pheromone concentration reaches 30 nM, all cells stay at on state. (B) The change of PrgB protein distribution for cCF10 concentration from 6 nM to 9 nM. (C) The dynamic behavior responding to constant concentration of pheromone, cCF10. This simulation is done with extracellular pheromone concentration maintained at 10 nM.