Analyzing the Functional Properties of the Creatine Kinase System with Multiscale ‘Sloppy’ Modeling
Figure 8
Pulsatile nature of energy production and consumption in the beating heart and the response to a step in heart rate.
Shown are the time courses of (A) ATP hydrolysis and (B) synthesis simulated with the model of Figure 1. At time 0 s, average ATP hydrolysis rate was increased from 486.5 to 627.6 µM*s−1 corresponding to an increase in heart rate from 135 to 220 bpm, as was imposed in the experiments which were simulated in this study. Please note the difference in scale of the y-axis between panels A and B.