Analyzing the Functional Properties of the Creatine Kinase System with Multiscale ‘Sloppy’ Modeling
Figure 5
Dependence of PCr diffusion flux on heart rate and mitochondrial membrane permeability to adenine nucleotides.
Prediction of the PCr contribution to high-energy phosphate flux across the mitochondrial outer membrane (Rdiff,PCr), averaged over the cardiac cycle, as a function of (A) heart rate and (B) mitochondrial outer membrane permeability for adenine nucleotides (PSmom,AdN), respectively. Values for (A) Steady state values for Rdiff,PCr as a function of heart rate (B) Steady state values for Rdiff,PCr as a function of PSmom,AdN at fixed heart rate of 220 bpm. We performed simulations for the ensemble of Figure 3, with the heart rate or PSmom,AdN set according to the x-axis. Blue shaded regions depict the 95% confidence interval of the prediction, black solid lines show the prediction for the optimized parameters (see Table 1).