Analyzing the Functional Properties of the Creatine Kinase System with Multiscale ‘Sloppy’ Modeling
Figure 2
Fit by the model of measured response times to heart rate steps.
The response times of oxidative phosphorylation (tmito) were measured in isolated rabbit hearts [9]. Model parameters were estimated using a modified Levenberg-Marquardt algorithm. Red bars represent the tmito values from the experiment, yellow bars represent the tmito values predicted by the model after the fitting procedure. Data is available for six different conditions: three different amplitudes of heart rate jump (from 135 bpm to 160, 190 and 220 bpm heart rate), each one measured with full wildtype CK activity (100%) or with CK activity inhibited to 2% of wildtype value. The error bars reflect the standard error of the measurements and the standard deviation of the tmito values in the ensemble, respectively.