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In Silico Evidence for Gluconeogenesis from Fatty Acids in Humans

Figure 8

Schematic representation of the iteration process for searching pathways.

Black arrows correspond to reactions belonging to the subsystems. A, D and F Subsystems used in the different iteration steps. B, C and E Selected elementary flux patterns (thick black arrows) and the reactions used by an associated elementary mode in the remaining system (thick gray arrows). If only one direction of a reversible reaction belongs to a subsystem, the reverse direction is omitted for clarity. G and H Elementary flux patterns of the final system producing R5P with the associated pathways through the entire system. A list of abbreviations can be found in Table S1.

Figure 8

doi: https://doi.org/10.1371/journal.pcbi.1002116.g008