In Silico Evidence for Gluconeogenesis from Fatty Acids in Humans
Figure 6
Pathway overview and storage efficiencies of selected compounds.
A Overview of ATP, NADPH and NADH consumption for gluconeogenesis from acetyl-CoA for all detected pathways (see Text S1). Furthermore, Gibbs free energy changes of all pathways for gluconeogenesis from acetyl-CoA and palmitate are given. B Gluconeogenic energy efficiencies and glucose storage efficiencies for selected compounds. Amino acids marked with an asterisk cannot be synthesized from glucose in humans. “Palmitic acid (eff.)” refers to the most energy efficient pathway for gluconeogenesis from fatty acids (pathway 7) and “Palmitic acid (ineff.)” to the most inefficient pathway (pathway 20).