Partially Glycosylated Dendrimers Block MD-2 and Prevent TLR4-MD-2-LPS Complex Mediated Cytokine Responses
Figure 3
Difference between the number of interactions of human MD-2 with the unmodified dendrimer and the partially glycosylated dendrimer.
Black columns – docking study performed with Hex; Grey columns – docking study performed with Patchdock. The Patchdock results showed a larger number of interactions with human MD-2 along its whole sequence. The Hex results showed a clear preference for interactions with residues lining the entrance to human MD-2's hydrophobic pocket (i.e., residues 84 to 127).