Partially Glycosylated Dendrimers Block MD-2 and Prevent TLR4-MD-2-LPS Complex Mediated Cytokine Responses
Figure 2
Interaction studies between the dendrimers and human MD-2.
(A) Solvent accessible surface area (SASA) was determined for each human MD-2 residue; (B) Docking studies performed with Patchdock; (C) Docking studies performed with Hex. Black columns – dendrimer modified with 8 glucosamines. Grey columns – unmodified dendrimer.