Partially Glycosylated Dendrimers Block MD-2 and Prevent TLR4-MD-2-LPS Complex Mediated Cytokine Responses
Figure 1
Solutions of the docking studies between the human TLR4-MD-2 complex and glucosamine molecules performed with GRID protocol.
The human TLR4-MD-2 complex is shown with its points of interaction with glucosamine molecules. Blue – human TLR4-MD-2 complex structure represented as ribbons; Red – interacting protein residues and glucosamine molecules with the latter shown as CPK, scaled to the number of molecules at each spot (0.9 for small spots, 1.7 for medium spots and 2 for large spots). The black ellipse highlights MD-2.