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The Eps8/IRSp53/VASP Network Differentially Controls Actin Capping and Bundling in Filopodia Formation

Figure 3

Average concentrations of filopodia initiator correlates with the probability of forming filopodia.

a. Distributions of the concentration of filopodia initiators (FI) in cell populations with different mean values (μ) and identical standard deviationσ, computed as . The concentration of FI required for initiating the positive feedback loop (FI_crit) is shown as a dotted line. As μ increases (different colored curves) the fraction of cells with FI>FI_crit increases. b. Fraction of cells in a population with FI>FI_crit as a function of the average FI concentration μ. Different color squares represent the fraction of cells for the different Gaussians shown in A. To calculate the amount of cells with FI>FI_crit, we simply integrate the Gaussian from FI_crit to infinite, .

doi: https://doi.org/10.1371/journal.pcbi.1002088.g003