Robust Network Topologies for Generating Switch-Like Cellular Responses
Figure 2
A. Each component is modeled as an enzyme or transcription factor. The input component A is modeled as a receptor to which the stimulus binds. B. Enzymatic components can catalyze the activation or inactivation of their targets, denoted as X. Transcriptional components can upregulate or inhibit the synthesis of the inactive forms of their targets. C. Sample network illustrating all possible interaction types. D. Four compositional classes were studied: EEE, in which A, B, C, are modeled as enzymes; TTT, in which each component is a transcription factor; and hybrid networks, in which only C is a transcription factor (EET) or both B and C are transcription factors (ETT). E. Overview of the topology search algorithm.