Colocalization of Protein Kinase A with Adenylyl Cyclase Enhances Protein Kinase A Activity during Induction of Long-Lasting Long-Term-Potentiation
Figure 6
Fraction of GluR1 phosphorylated on Ser845 for 5 individual trials (shown in different colors) fluctuates due to stochastic nature of simulations.
Black traces shows the average of 5 trials which differ only in the random seed used to start the simulations. (A) When PKA and adenylyl cyclase are colocalized in the spine, GluR1 phosphorylation increases for each trial. (B,C) When PKA is separated from adenylyl cyclase, most trials show a decrease in GluR1 phosphorylation; but some trials show an increase. (D) When PKA is colocalized with adenylyl cyclase in the dendrite, most trials show an increase in GluR1 phosphorylation; but some trials show a decrease.