Colocalization of Protein Kinase A with Adenylyl Cyclase Enhances Protein Kinase A Activity during Induction of Long-Lasting Long-Term-Potentiation
Figure 2
A schematic representation of the four spatial variations in location of adenylyl cyclase and PKA used for the simulations.
PKA is located either in the spine head or a focal dendritic area. Similarly adenylyl cyclase (AC) is located either in the spine head or a focal dendritic area. D1R and G proteins are colocalized with AC in every case. GluR1 receptors are in the PSD compartment of the spine head for each case. Location and quantity of calcium influx (Figure 1B) is the same for all four cases.