Colocalization of Protein Kinase A with Adenylyl Cyclase Enhances Protein Kinase A Activity during Induction of Long-Lasting Long-Term-Potentiation
Figure 1
Model of CA1 pyramidal neuron dendrite plus spine.
(A) Diagram of postsynaptic signaling pathways. Each arrow is modeled with one or more bimolecular or enzyme reactions. Diffusion is not illustrated in this diagram. (B) Morphology of dendrite with attached spine and location of calcium influx in the model. Dendritic subvolumes are cuboids, whereas the spine subvolumes are either cylindrical or conical, as portrayed. Dotted lines show part of the compartmentalization. Subvolumes adjacent to the top and bottom surface of the dendrite are considered submembrane subvolumes. Other dendritic subvolumes are part of the cytosol. Calcium injection in a focal dendritic region represents influx through voltage dependent calcium channels. Calcium injection in the PSD represents influx through NMDA receptors. Diffusion is two-dimensional in the dendrite and one-dimensional in the spine, with reflective boundary conditions. (C) Morphology of dendrite with multiple spines used for evaluating spatial specificity. Stimulated spines are indicated by arrows. The different colored subvolumes serve to illustrate the boundaries.