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Cellularly-Driven Differences in Network Synchronization Propensity Are Differentially Modulated by Firing Frequency

Figure 7

Time to synchronization for differentially-driven Type II cortical pyramidal cell networks.

(A) Bursting parameter B as a function of the re-wiring parameter for four Type II networks driven with different values of applied current (). Note how for values of the re-wiring parameter greater than approximately 0.40, there was little difference among the values of B for different values of , especially for the three largest values of . (B) Average time taken for the bursting parameter of Type II networks with randomly-distributed initial conditions to breach 0.6. Initial conditions were randomized such that initial membrane voltage values were uniformly distributed on the interval [−70 mV, −50 mV], with gating variables set to corresponding equilibrium values. Each data point is an average of 100 simulations. Note that panel B plots the subset of values of the re-wiring parameter from panel A for which the bursting parameter assumes approximately constant values.

doi: https://doi.org/10.1371/journal.pcbi.1002062.g007