Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation
Figure 6
Undiseased human endocardial AP traces from experiments (small tissue preparations) and model simulations.
Simulated APs for a range of pacing frequencies (top) and corresponding examples of experimentally recorded APs at 37°C (below). Arrows indicate cycle length (CL) changes. B) Comparison of simulation (black) and experimentally measured (gray, small tissue preparations) basic AP parameters for a single paced beat from quiescence (37°C, N = 32 from 32 hearts). Shown, from top to bottom, are the resting membrane potential (Vm rest), maximum upstroke potential (Vm max), and maximum upstroke velocity (dVm/dt max).