A Role for Both Conformational Selection and Induced Fit in Ligand Binding by the LAO Protein
Figure 7
A schematic diagram describing the proposed two-step binding mechanism for proteins in steric occlusion of the direct binding of the ligands.
The first step is the transition from the apo to the encounter complex state. In this step, multiple pathways exist where both conformational selection and the induced fit mechanisms play important roles. The second step is the transition from the encounter complex to the bound state, where the induced fit mechanism is adopted.