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Quantitative Epistasis Analysis and Pathway Inference from Genetic Interaction Data

Figure 1

Theoretical model used to interpret epistasis in signal-responsive pathways.

Lines ending in circles indicate influences that can be activating or repressing. Dotted lines indicate Boolean relationships defined in Eq. (4). Variables and influences are defined in the text (α_I is omitted for clarity).

doi: https://doi.org/10.1371/journal.pcbi.1002048.g001