Temporal Encoding in a Nervous System
Figure 1
Statistics of doublet spiking.
A: ±1 SD envelope showing intracellular voltage waveform relative to resting membrane potential of isolated single spikes (blue) and isolated short doublets of ISI 2.6 ms (red) from a single recording in interneuron of class 10-2a. Dashed black line denotes mean resting membrane potential (0 mV). B: ±1 SD of intracellular waveform from same recording as in A, this time with a doublet of ISI 6.5 ms (red, n = 26). C: ISI histogram of data from recording in A and B at 0.1 ms resolution (black line, n = 26,171 events), as well as compilation data from 40 cells of class 10-2a and 10-3a (gray shaded area, n = 577,435 events). D: Normalized ISI histogram of population data from panel C, with time scale reduced to 1–5 ms. Red line shows the recovery function, with black dashed line showing limits of fit to recovery function. E: Difference between independent model and measurements from data of joint probability of consecutive ISIs. Positive (red) values represent overestimation by the independent model, while negative (blue) values represent underpredictions by the independent model.