MDCK Cystogenesis Driven by Cell Stabilization within Computational Analogues
Figure 12
ISMA cell division. Cell division depends on the cell neighborhood.
Single isolated cells (top) that have not divided have no midbody and divide with a random axis of division. When cells divide they find their centroid and store it as the midbody of their daughter cells. Cells that have previously divided and have a midbody utilize it for subsequent divisions. For these organized divisions (top), the axis of division is determined by a line drawn from a cell's current centroid to the stored midbody. Cells in contact with a lumen will also divide in an organized fashion (bottom), using a line between their centroid and that of the lumen to determine the axis of division. When the axis of division is determined, all points on one side of the line are assigned to a new cell while all points on the other remain assigned to the original cell.