Modification of Gene Duplicability during the Evolution of Protein Interaction Network
Figure 6
Dosage regulation of the atrophin genes.
Atrophins are metazoan-specific genes that underwent duplication in vertebrates. The fly ortholog Atro is highly dosage sensitive: increased and reduced expression due to modifications of miR-8 lead to neurogenerative and survival defects [38], [39]. Rere, one of the two vertebrate atrophin paralogs, is target of mir200b and miR-429, the vertebrate counterparts of miR-8. Dosage modifications of Rere lead to re-localization of the other paralog, ATN1, in the nucleus, upon direct binding [41]. Interestingly, ATN1 is the gene responsible for the dentatorubral-pallidoluysian atrophy (DRPLA) [40].