Modification of Gene Duplicability during the Evolution of Protein Interaction Network
Figure 5
Dosage regulations of human hubs.
(A) The fraction of human duplicated hubs that are ohnologs, miRNA targets, and tissue-selective genes is compared to the corresponding fraction of singleton hubs. Although the main contribution is due to ohnologs (B), the enrichment still remains detectable when miRNA targets (C) and tissue-selective genes (D) are considered separately. Small-scale duplications refer to duplicated hubs that are not the result of whole-genome duplication (i.e. they are not within the dataset of ohnologs). Since the number of hubs that originated with opisthokonts and primates is only 43 and 17, we group them with hubs that originated with eukaryotes and mammals, respectively. * significant enrichment when compared to older genes (Fisher's exact test).