Modification of Gene Duplicability during the Evolution of Protein Interaction Network
Figure 3
Relationship between gene origin and conservation and network properties.
Degree (connectivity) and betweenness (centrality) are compared between (A) proteins that originated at a given node and younger or older proteins; and (B) proteins with a given conservation and less or more conserved proteins. In both analyses, the differences are assessed with the Wilcoxon test and the resulting p-values are transformed into heatmaps. Each square represents genes that originated at a given internal node or with a given level of conservation. The color represents the p-value. Red is associated with more connected or more central proteins, green is associated with less connected or less central proteins. The lower bound of p-values is set equal to 10−3.