“Fluctuograms” Reveal the Intermittent Intra-Protein Communication in Subtilisin Carlsberg and Correlate Mechanical Coupling with Co-Evolution
Figure 7
The calculated hit rates ('s) and coverages (
's) by using Criterion-C, (eq.(4)).
(a) 's from the apo fluctuogram. (b)
's from the Ca2+-bound fluctuogram. Hit rates achieved by randomly picking the same numbers as the selected residues based on
= 7 kcal/mol/Å2 are also shown for comparison. The profiles correspond to other
values are quantitatively close. (c)
's from the apo fluctuogram. (d)
's from the Ca2+-bound fluctuogram.