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Noise Contributions in an Inducible Genetic Switch: A Whole-Cell Simulation Study

Figure 16

Probability landscape of protein–mRNA abundances in the inducible lac switch model.

(A) Steady-state probability landscape (arbitrary units, darker = higher) for the NPF model at 500 TMG. The dotted line shows the trajectory of a representative cell during a ∼3 hour interval starting at the open circle and ending at the closed circle. (B) Probability landscape of the PFB circuit over a period of 24 hours following the addition of external TMG to 16 . The line follows a single cell switching from the uninduced to the induced state over the course of ∼13 hours.

Figure 16

doi: https://doi.org/10.1371/journal.pcbi.1002010.g016