Noise Contributions in an Inducible Genetic Switch: A Whole-Cell Simulation Study
Figure 14
Analysis of cryoelectron tomography based cell model.
(A) Slow growth E. coli cell model based in part on data from a tomographic reconstruction. Shown are (orange) ribosomes, (light gray) membrane, (dark grey) condensed nucleoid, and (red) lac operator. (B+C) Distribution of repressor–operator complex lifetimes for the fast and slow growth models, respectively. Curves show fits to an exponential distribution with the given mean. (D) Position of mRNA–membrane contact after diffusion of mRNA produced at the lac operon in (blue x) fast growth and (red o) slow growth models. Dotted lines show the length of the respective cells.