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Noise Contributions in an Inducible Genetic Switch: A Whole-Cell Simulation Study

Figure 12

The effect of in vivo crowding on repressor rebinding.

Each line represents the mean of 5000 trajectories. (A) The observed diffusion coefficient, , as a function of time scale for a repressor diffusing in a volume with the indicated fraction occupied by in vivo obstacles. (B) –exponent arising from fitting to a model of anomalous diffusion, . (C) The probability for a repressor to rebind with the operator before diffusing into the bulk (64 nm from operator) following unbinding, as a function of the in vivo packing. (D) The distribution of escape times for repressors that diffuse to bulk rather than rebind, at three packing values.

doi: https://doi.org/10.1371/journal.pcbi.1002010.g012