Noise Contributions in an Inducible Genetic Switch: A Whole-Cell Simulation Study
Figure 11
Effect of positive feedback on GRF noise.
(A) Mapping of the mean internal inducer concentration for a given external concentration for the (green) uninduced and (red) induced subpopulations. (black dotted) The values for the lac circuit without positive feedback are shown for reference. (B) The mean number of LacY in the subpopulations as a function of internal inducer concentration. (C) The noise in the LacY distribution.