Noise Contributions in an Inducible Genetic Switch: A Whole-Cell Simulation Study

doi:10.1371/journal.pcbi.1002010

Noise Contributions in an Inducible Genetic Switch: A Whole-Cell Simulation Study

Figure 10

Response of an uninduced PFB population to the addition of external inducer.

(A) Probability density (arbitrary units, darker = higher) of the number of LacY in a cell over the course of 24 hours. Shown are representative responses for populations in the uninduced range (0–10 ; left), the bimodal range (10–25 ; center), and the concerted induction range (>25 ; right). Lines show the mean value of the (green) uninduced and (red) induced subpopulations. (B) Fraction of the cells in each of the subpopulations. (C) The (solid) mean and (dotted) variance of LacY in the uninduced subpopulation.

doi: https://doi.org/10.1371/journal.pcbi.1002010.g010