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Noise Contributions in an Inducible Genetic Switch: A Whole-Cell Simulation Study

Figure 9

Steady state LacY distributions from the well-stirred NPF model.

Distributions at inducer concentrations of (A) 0, (B) 100, and (C) 200 TMG. Shown are (gray bars) histograms from 10,000 Gillespie trajectories and (red dash) gamma distributions from Choi et al. [22]. (D) Mean LacY as a function of inducer concentration along with 95% ranges. (E) The noise in the LacY distributions as quantified by the Fano factor (variance over the mean). (F) The fraction of time spent in the transcriptionally active state.

Figure 9

doi: https://doi.org/10.1371/journal.pcbi.1002010.g009