Noise Contributions in an Inducible Genetic Switch: A Whole-Cell Simulation Study
Figure 7
Burst analysis of stochastic simulations of a simple two-state process.
The two-state process was described by: . Rate constants were chosen such that on average
bursts of Z with a constant burst size
were produced during Z's mean lifetime with the mean duration of each burst lasting for the indicated fraction of the lifetime. At each point, 250 stochastic simulations were run until the probability density was stationary and then the distributions of Z were fit to gamma distributions to obtain the
and
parameters. The ratios of (A)
/
and (B)
/
as a function of the burst duration show the range of burst durations for which a gamma distribution fit can reliably recover the original parameters. In this example
and
.