Noise Contributions in an Inducible Genetic Switch: A Whole-Cell Simulation Study
Figure 1
Three models for stochastic gene expression.
(A) Burst model in which transcription of the DNA is always active. (B) Two-state model in which the DNA switches with constant rates between active and repressed states. (C) Inducible genetic switch in which an inducer both controls the rate of switching between active and inactive transcription states and is also positively regulated by the protein product – a positive feedback loop (PFB). The gray dotted connection indicates a weak effect of the inducer in promoting the unbinding of repressor at high inducer concentrations.