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A Toolbox Model of Evolution of Metabolic Pathways on Networks of Arbitrary Topology

Figure 8

Various linear relationships on the individual pathways.

Approximately linear relationship between a) pathway's length and its number of reactions , ) b) the number of border reactions, n_{border rxn,} and the total number of reactions, , c) the number of base metabolites, n_base, and the total number of metabolites, , d) the number of metabolites receiving feedback, n_feedback, and the total number of metabolites, . These different geometrical properties of individual pathways are illustrated in Figure 4. Sizes of circles are proportional to the logarithm of the number of discrete (x, y) pairs contributing to this point.

doi: https://doi.org/10.1371/journal.pcbi.1001137.g008