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Transcriptional Regulation: Effects of Promoter Proximal Pausing on Speed, Synchrony and Reliability

Figure 6

Sensitivity analysis for mean expression time.

Histograms of the marginal distributions of relative sensitivities for both the ER and IR schemes, across uniform random samples from parameter space, as described in the text. The smallest bin of the histogram (values below ) is disproportionately large, and so is omitted; shown instead is the percent of parameter space on which the relative sensitivity is at least . Note that often only a single parameter dominates (many sensitivities are near 1), that many parameters are almost never influential, and that ER and IR are similar except for the addition of sensitivity to .

doi: https://doi.org/10.1371/journal.pcbi.1001136.g006