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Transcriptional Regulation: Effects of Promoter Proximal Pausing on Speed, Synchrony and Reliability

Figure 5

Effect of scaffold stability for variation in transcript number.

(A) ratio of transcript variability, , between the IR and ER model when all subsequent polymerases engage an assembled scaffold . Extreme values that would be off the edge of the graph are collected into the outermost bins. (B) As in (A) when , note the ER scheme is more often substantially more coordinated, though a few parameters still make the IR scheme the more coordinated by a smaller margin. (C) . (D) .

doi: https://doi.org/10.1371/journal.pcbi.1001136.g005