Transcriptional Regulation: Effects of Promoter Proximal Pausing on Speed, Synchrony and Reliability
Figure 4
(A) Comparison of log ratios of mean expression speed for the IR/ER schemes for 10,000 uniformly sampled rates. For all jump rates, the log ratio is positive (red line), indicating the ER scheme is always faster. Extreme values that would be off the edge of the graph are collected into the outermost bins. (B) Variance in timing of expression. (C) ratio of noise in transcript number, measured by the squared coefficient of variation between cells of total mRNA counts
up to time
:
– the ratio is approximately independent of
.