Transcriptional Regulation: Effects of Promoter Proximal Pausing on Speed, Synchrony and Reliability
Figure 2
Each possible complex in the process is enumerated as a state of the promoter Markov chain. (see text for description of each complex) The promoter chain (states 1–8) is combined with the enhancer chain (states A and B) to make the full 16 state model of transcription. Transitions that in some scheme require an activated enhancer (state B) are indicated by a gate, . Forward rate transitions are in light font and backward transitions in dark font. The
transition is regulated in the IR scheme, and the
transition is regulated in the ER scheme.