Causal Modeling Using Network Ensemble Simulations of Genetic and Gene Expression Data Predicts Genes Involved in Rheumatoid Arthritis
Figure 8
GON4L predicted modulate both tender and swollen joint count in TNF-α treated patients.
Plots of simulated number of tender joints, swollen joints, pain and C-reactive protein concentrations in response to a 10-fold knockdown in gene expression of GON4L, recently described as a novel factor in B-cell differentiation, in A. pretreated subjects and B. TNF-α blocker treated subjects. The simulations suggest that this novel gene can modulate both tender and swollen joint count in TNF-α treated subjects. GON4L may provide insight into novel TNF-α independent signaling pathways in RA.