Causal Modeling Using Network Ensemble Simulations of Genetic and Gene Expression Data Predicts Genes Involved in Rheumatoid Arthritis
Figure 7
RAP2C predicted to modulate both tender and swollen joint counts in TNF-α treated patients.
Plots of simulated number of tender joints, swollen joints, pain and C-reactive protein concentrations in response to a 10-fold knockdown in gene expression of RAP2C, a recently described ras G-protein, in A. pretreated subjects and B. TNF-α blocker treated subjects. The simulations suggest that this novel gene can modulate both tender and swollen joint count in TNF-α treated subjects. RAP2C may provide insight into novel TNF-α independent signaling pathways in RA.