Causal Modeling Using Network Ensemble Simulations of Genetic and Gene Expression Data Predicts Genes Involved in Rheumatoid Arthritis
Figure 5
Tender joints predicted to be modulated by WARS in pre-treated patients only.
Plots of simulated number of tender joints, swollen joints, pain and C-reactive protein concentrations in response to a 10-fold knockdown in gene expression of tryptophanyl-tRNA synthetase, WARS, in A. pretreated subjects and B. TNF-α blocker treated subjects. The modulation of tender joints is only predicted in pre-treated patients, suggesting a dependence on TNF-α signaling.