Dynamic Conformational Changes in MUNC18 Prevent Syntaxin Binding
Figure 9
Munc18aF115E adopts a closed-cavity conformation.
Two snapshots taken from a 20-ns-simulation of munc18aF115E demonstrate the closure of the cavity between domains 3a and 1 during the simulation of this mutant as well. A) t = 0, B) t = 20 ns, the cavity area is framed in both A and B. C) Measurement of the distance between the centers of mass of domains 3a and 1 during the Munc18aF115E simulation.