Dynamic Conformational Changes in MUNC18 Prevent Syntaxin Binding
Figure 2
Comparison of free munc18a dynamics to its squid homologs' crystal structures.
A) Superposition of the backbone of four crystal structures presented in ribbon form; green, blue and red: the three resolved crystal structures of the squid sSec1: green (1EPU.pdb), blue (1FVF.pdb) and red (1FVH.pdb); yellow: the crystal structure of munc18a taken from the complex with syntaxin ([12], 3C98.pdb). B) Snapshots of domain 3a taken from the last frame of the first eigenvector in each of the three wild-type simulations; blue: 1, red: 2, black: 3. C) Snapshots of domain 1 taken from the last frame of the main eigenvectors of each of the three MD simulations; blue: 1, red: 2, black: 3.